There is an emergency patient who needs treatment immediately at Chungil Penitentiary. The warden calls 911, but Yo Han secretly appears and treats the patient. Si Young plans a trip to Madagascar, but she is short of money. At that moment, Jeong Nam calls Si Young and offers her a part-time job.

Si Young wants to go back to the hospital again, but she thinks she doesn't deserve to save patients. She thinks that never wearing a doctor's gown again is a punishment for herself. At the penitentiary, Inmate 5353 visits Si Young because of a rash, and Yo Han tells her that Inmate 5353 needs to go to an outside hospital urgently.

Yo Han and Si Young think that Inmate 5353 is suffering from Fabry disease. Si Young tells Yoo Joon that the patient has Fabry disease, but Yoo Joon tells her there are only 100 people in the whole country who have the disease. Meanwhile, Si Young gets to know why Yo Han was imprisoned.

Yo Han is sure that Jung Bo’s is suffering from Fabry disease, and he suggests to Si Young that she should run an enzyme test for the last time. Si Young goes to Kyungwon Hospital again, but Jung Bo is nowhere to be found all of a sudden. Meanwhile, Tae Kyung announces Si Young's comeback to the hospital.

A mixed martial arts fighter Joo Hyung Woo gets injured during his match. Yo Han tells Hyung Woo that he needs to be treated right away if he doesn’t want to lose his sight. Many doctors in Seoul Hanse Medical Center oppose Yo Han’s reinstatement, but he comes back to the hospital thanks to Tae Kyung.

Tae Kyung warns Yo Han not to cause any trouble. Yo Han wants Si Young to stay out of Hyung Woo’s case because he doesn’t want her to get into trouble too. Si Young encounters Eun Jeong, and Eun Jeong tells Si Young what happened to Yo Han three years ago.

Hyung Woo’s wife wants to respect Hyung Woo’s will, but his father wants to save him. Yo Han keeps trying to find out the name of Hyung Woo’s disease. Meanwhile, Hyung Woo’s condition gets worse again, and Yo Han wants to treat him once again.

Jeong Nam asks Yo Han to take good care of Si Young, and Yo Han tells him that Si Young is doing great. Si Young asks Yo Han if he doesn’t have any regrets about his decision three years ago. She is afraid of the fact that a patient’s life is in her hands, and Yo Han tells Si Young that a patient needs a doctor just like her.

Mi Rae tells Si Young that she wants Yi Soo to stay alive even if he is bedridden. Doctors in Seoul Hanse Medical Center start questioning about Yi Soo’s life-prolonging treatment, and Tae Kyung seems to be confused. Si Young wants to find the restaurant where she and Yi Soo had dinner for the last time, and Yo Han helps her to find the restaurant.

The patient who insists he has CRPS comes to see Yo Han. At the same time, a student whose arm is badly hurt comes to the Pain Management Center, and Yo Han thinks he has CIPA. Si Young and Mi Rae carry out Seung Won’s examination together, and Mi Rae thinks Si Young’s excessive empathy disturbs an accurate diagnosis.

Seok Ki tells Yo Han that only society’s forgiveness can erase Yo Han’s criminal record. No matter what Seok Ki says to him, the only thing that matters to Yo Han is what kind of doctor he is to his patients. Gi Seok feels no pain because of CIPA, but he can feel pain all of a sudden. However, CIPA is an incurable disease, so Yo Han is confused.

Gi Seok doesn’t want to get surgery because he doesn’t want to go back to his old days. Yo Han shows Gi Seok something and persuades him to get surgery. The Pain Management Center’s members have a team dinner at Yoo Joon’s mother’s restaurant. During the dinner, Mi Rae asks Yo Han if euthanasia was a final prescription for the patient.

Yo Han tells Si Young to keep his condition a secret. Si Young worries about Yo Han after she knew about his disease. Yo Han calls in sick, and Si Young goes to his house because she worries about his condition. However, Yo Han tells her not to over react. Meanwhile, Seok Ki visits Tae Kyung.

Deok Kyu comes to the Pain Management Center to receive treatment, and the other patients who took the same bus with him seem to have fever.

Yo Han wants to go inside the center, but Seok tells him no one can enter the center under any circumstances. Yo Han goes inside the center despite Seok’s opposition, and Si Young worries about him since the virus can be dangerous to him. Meanwhile, Yo Han keeps trying to diagnose the suspected patient’s disease

Heo Jun tries to cure his patient’s phantom limb pain. Si Young worries about Yo Han, so she checks his BP and pulse to see if his condition is fine. Si Young wants to understand Yo Han, but Yo Han tells her that she can’t understand him. Meanwhile, Seok Ki goes to Death Talk’s gathering, and he gets to meet one person who is critically ill.